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Article
February 1913

UNSATURATED FATTY ACID AS A NEUROLYTIC AGENT

Author Affiliations

BOSTON

From the Laboratory of the Danvers State Hospital. No. 24 of the Danvers State Hospital Series.

Arch Intern Med (Chic). 1913;XI(2):187-192. doi:10.1001/archinte.1913.00060260068004
Abstract

This communication is a brief report of some experiments conducted with the purpose of determining whether certain hemolytic substances had a lytic effect on the nerve cell and what the consequences of this lytic action might be in the surrounding tissue. Experiments were conducted on five cats. The substances employed were oleic acid and triolein. Oleic acid, as is well known, is hemolytic, whereas triolein is not. Oleic acid is an unsaturated fatty acid, and on that account, as Faust and Tallquist1 have shown, is hemolytic. It is capable of forming soaps with bases, and therefore of going into colloidal solution in the body fluids. Triolein is a combination of three molecules of oleic acid attached to a molecule of glycerin. It is a neutral fat; that is, it is not capable of forming soaps with bases and therefore can not go into colloidal solution in the body

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