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March 1913

STUDIES OF RENAL FUNCTION IN RENAL, CARDIORENAL AND CARDIAC DISEASES

Arch Intern Med (Chic). 1913;XI(3):258-287. doi:10.1001/archinte.1913.00060270012002
Abstract

Renal function has been studied in fifty-seven patients, the cases including pure nephritis, cardiac and cardiorenal diseases, the tests used being phenolsulphonephthalein, lactose, salt, water, potassium iodid and the accumulation in the blood of uncoagulable nitrogen. In certain cases, the excretion of indigo carmin and rosanilin was studied, as was also the glycosuria following the injection of phloridzin. It became apparent early that nothing was to be gained from the continued use of these dyes, as they were excreted roughly in proportions paralleling the excretion of phthalein and both much more slowly. Moreover, they were irritating to the patients. The use of indigo carmin was discarded also, because its colorimetric properties are not well adapted to accurate quantitative work.1 The glycosuria following the administration of phloridzin seems to bear some relation to the excretion of lactose under similar conditions, i. e., glycosuria is prolonged. Phloridzin glycosuria, however, is exceed

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