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Article
May 1913

A CLINICAL INVESTIGATION OF THE CARBONIC ACID IN THE ALVEOLAR AIR

Author Affiliations

BOSTON BALTIMOREORE

From the Physiologic Laboratory of the Medical Clinic, Johns Hopkins University, and the Medical Service of the Johns Hopkins Hospital.

Arch Intern Med (Chic). 1913;XI(5):551-563. doi:10.1001/archinte.1913.00060290085011
Abstract

The experiments of Mosso, Haldane and his collaborators, and of Yandell Henderson have shown that the maintenance of a definite percentage of carbon dioxid in the alveolar air of the lungs and in the blood is of prime importance to the organism and is maintained by a definite physiological regulation. They have also shown that overventilation of the lungs by hyperpnea, which reduces the concentration of the CO2 in the alveolar air below normal, gives rise to a feeling of weakness and giddiness exactly like that of mountain sickness, and when pushed to extremes, also to periodic breathing of the Cheyne-Stokes type.

Yandell Henderson has produced a good deal of evidence to indicate that the clinical manifestations of surgical shock may be brought about by a condition of acapnia; and Porges, Leimdörfer and Marcovici have found acapnia present in cases of acidosis and in certain cases of cardiac

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