The experiments of Mosso, Haldane and his collaborators, and of Yandell Henderson have shown that the maintenance of a definite percentage of carbon dioxid in the alveolar air of the lungs and in the blood is of prime importance to the organism and is maintained by a definite physiological regulation. They have also shown that overventilation of the lungs by hyperpnea, which reduces the concentration of the CO2 in the alveolar air below normal, gives rise to a feeling of weakness and giddiness exactly like that of mountain sickness, and when pushed to extremes, also to periodic breathing of the Cheyne-Stokes type.
Yandell Henderson has produced a good deal of evidence to indicate that the clinical manifestations of surgical shock may be brought about by a condition of acapnia; and Porges, Leimdörfer and Marcovici have found acapnia present in cases of acidosis and in certain cases of cardiac
GREY EG, HIRSCHFELDER AD. A CLINICAL INVESTIGATION OF THE CARBONIC ACID IN THE ALVEOLAR AIR. Arch Intern Med (Chic). 1913;XI(5):551-563. doi:10.1001/archinte.1913.00060290085011