August 1913


Author Affiliations


From the Pathological Laboratory of the University of Wisconsin.

Arch Intern Med (Chic). 1913;XII(2):236-242. doi:10.1001/archinte.1913.00070020122012

The publication at this time of the result of our endeavors to cultivate an organism from the tissues of patients with Hodgkin's disease is occasioned by the publication by Negri and Mieremet1 of the successful cultivation from two cases of Hodgkin's disease of a diphtheroid organism which they designate as the Corynebacterium granulomatis maligni.

While Hodgkin's disease, or malignant granuloma of the lymphatic apparatus, has of late years come to be generally regarded as of infectious nature, the etiological agent has remained undetermined. The work in this country of Reed2 and of Longcope3 showed definitely that the condition was independent of tuberculosis, and that the theory supported by Sternberg4 that it was a manifestation of the activity of the tubercle bacillus could not be maintained.

In 1900 Fraenkel and Much5 reported that by treating Hodgkin's nodes with a strong alkalin solution of sodium hypochlorid

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