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September 1913

THE REACTION OF SALOMON AND SAXL AS A DIAGNOSTIC TEST FOR CARCINOMA

Arch Intern Med (Chic). 1913;XII(3):283-287. doi:10.1001/archinte.1913.00070030040005
Abstract

Salomon and Saxl1 have described a reaction in the urine which they consider to be characteristic of carcinoma. The reaction depends on the supposed presence in the urine of such patients of a sulphur-containing substance, which does not yield inorganic sulphate on treatment with dilute hydrochloric acid, but which, on subsequent treatment with hydrogen peroxid, is oxidized, with liberation of inorganic sulphate. They report positive results in 70 per cent, of cases of carcinoma. They state that the reaction is frequently positive in the urine of pregnant women and in the urine of patients with cirrhosis or abscess of the liver. In a second paper2 they describe the following modification of their previous method :

One hundred c.c. of the albumin-free urine are measured into a 400 to 500 c.c. beaker, 10 c.c. of hydrochloric acid (spec. grav. 1.12) are added, the contents of the beaker are heated

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