In the year 1911, at the meeting of the Deutsche Naturforscher und Aerzte, I submitted a review on the subject of Thrombosis. The question was brought up because the increasing number of operations in surgical and gynecological practice has made a fatal embolism of the lung, the sequel of a thrombosis, of more and more frequent occurrence.
The more we try to obviate this dangerous complication, the more urgent is our obligation to find out the cause of thrombosis. Now, there is no doubt at all, to use a mathematical figure of speech, that thrombosis is the function of a number of variables. There is not a single cause, but quite a number of different conditions which are closely related to the occurrence of thrombosis. Among these may be mentioned here, first, changes in the blood-plasma (diminished or increased coagulability) ; secondly, changes in the blood elements (increased or diminished powers
ASCHOFF L. THROMBOSIS. Arch Intern Med (Chic). 1913;XII(5):503-525. doi:10.1001/archinte.1913.00070050020003