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November 1913


Author Affiliations


From the Department of Pathology, University of Michigan.

Arch Intern Med (Chic). 1913;XII(5):539-545. doi:10.1001/archinte.1913.00070050056005

The progressive increase in the incidence of carcinoma as the middle period of life is approached and reached has long been recognized. Most writers have contented themselves with a statement of this fact, leaving the reader to understand that even in advanced years the progressive increase is maintained. For instance, Bashford1 says : "Carcinoma appears in the human subject with increasing frequency as life advances." He recognizes, however, that the carcinoma incidence in those organs which undergo a definite phase of involution long before senile changes in the organism as a whole are marked, is highest during such involutionary processes. This he bases on statistics of breast and uterine cancer.

Senn2 gives a suggestion that in extreme old age the cancer incidence is decreased, as the following quotation shows : "Carcinoma manifests a predilection for the conditions incident to senile marasmus, occurring most frequently in persons between 50 and 70

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