In order to obtain a comprehensive insight into the pathogenesis of the various types of contracted kidney in man, it is first of all necessary to attack the problem from the experimental standpoint, and to attempt to produce in animals artificially the identical types of contracted kidney which are observed in human pathology. Unfortunately, up to the present time this has been possible only to an exceedingly limited extent. But in this regard certain pieces of work of the past year or two have served to advance our knowledge, amongst which that of my friend Ophüls in San Francisco, of my colleague Mackenzie in Toronto, of their pupil Dickson, and of Christian are especially worthy of mention.
On the other hand, more exact studies concerning the finer morphological structure of the kidney have appeared almost simultaneously in France and in Germany, and these undoubtedly must now form the essential
ASCHOFF L. THE PATHOGENESIS OF THE CONTRACTED KIDNEY. Arch Intern Med (Chic). 1913;XII(6):723-738. doi:10.1001/archinte.1913.00070060115008