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December 1913

SOME FORMS OF URINARY NITROGEN AFFECTED BY THE ADMINISTRATION OF DESICCATED THYROID TO DEMENTIA PRAECOX PATIENTS

Author Affiliations

KANKAKEE, ILL

From the Illinois State Psychopathic Institute.

Arch Intern Med (Chic). 1913;XII(6):746-750. doi:10.1001/archinte.1913.00070060138010
Abstract

In a previous article, I showed that indol-acetic acid is frequently present in the urine of dementia praecox patients.1 Later it was discovered that in the case of two dementia praecox patients the indol-acetic acid was endogenous and not derived directly from the tryptophan ingested.2 Since there has been much discussion as to the relation of dementia praecox to the internal secretions and especially to that of the thyroid gland and since the administration of desiccated thyroid has given contradictory results as to its effect on nitrogen metabolism, it was thought worth while to determine the influence of the administration of thyroid primarily on the indol-acetic acid, and secondarily on the creatinin and total urinary nitrogen excretion.

PLAN OF TESTS  Four women patients, classified as cases of dementia praecox, were selected. They were all in apparently perfect physical condition. Their ages ranged from 29 to 32 years.

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