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Article
January 1914

THE GONOCOCCUS COMPLEMENT-FIXATION TEST AND ANALYSIS OF RESULTS FROM ITS USE

Author Affiliations

PHILADELPHIA

From the Department of Genito-Urinary Surgery of the Philadelphia Poly-clinic Hospital and the William Pepper Clinical Laboratory of Medicine, University of Pennsylvania.

Arch Intern Med (Chic). 1914;XIII(1):143-158. doi:10.1001/archinte.1914.00070070148008
Abstract

In recognition of the recent admirable work by Schwartz and McNeil on the complement-fixation test in gonococcic infections, the fact must not be overlooked that Müller and Oppenheim, in 1906, were the first to apply this reaction to a gonorrheal affection and consequently are entitled to the distinction of being termed the originators. The present popularity of this test has been the outgrowth of the suggestion made by Schwartz and McNeil — namely, that of the employment of a polyvalent antigen. As a result of their labors, these workers contend, and seem to have proved conclusively, through animal experimentation: (1) "that the different strains of the gonococcus differ markedly one from another — so much so that the antibodies produced in the body by the toxin of one strain will in many instances not bind the complement in the presence of an antigen prepared from another strain. Therefore, if

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