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Article
February 1914

THE NON-PROTEIN NITROGENOUS CONSTITUENTS OF THE BLOOD IN CHRONIC VASCULAR NEPHRITIS (ARTERIOSCLEROSIS) AS INFLUENCED BY THE LEVEL OF PROTEIN METABOLISM

Author Affiliations

BOSTON

From the Laboratories of Biologic Chemistry and Theory and Practice of Harvard Medical School and the Long Island Hospital.

Arch Intern Med (Chic). 1914;XIII(2):224-234. doi:10.1001/archinte.1914.00070080049003
Abstract

By virtue of the analytical technic recently introduced by Folin and Denis for the analysis of blood it has become possible to study the retention of nitrogenous waste products with far greater ease and certainty than formerly. Such studies are particularly to be desired in the investigation of nephritis, for urine analyses cannot reveal the stage of accumulation of such products, an accumulation which may vary between almost normal figures and those accompanying uremia. According to Strauss, the high blood-pressure of nephritis is usually or at least frequently accompanied by an excessive accumulation of the nitrogenous waste products, whereas edema is rather associated with a retention of chlorids. For the investigation reported in this paper we have selected a group of patients whose blood-pressure varied between 160 and 225 mm.

The chief purpose of our investigation was to determine the extent to which it is possible by

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