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March 1914


Arch Intern Med (Chic). 1914;XIII(3):426-470. doi:10.1001/archinte.1914.00070090079006

PATHOGENESIS  Notwithstanding that a great deal of experimental work has been done to explain the pathogenesis of gastric ulcer, the real etiology is as yet not clear. We, therefore, consider it a duty to analyze the work and theories advanced, and if possible draw conclusions which will somewhat elucidate the subject.The fact that ulcus rotundum only occurs in the stomach and its immediate vicinity has given rise to the theory that the gastric juice had something to do with the formation of the ulcer, hence the name "ulcus pepticum."The question soon arose : What is it that really protects the gastric mucosa against autodigestion? Various authors have tried to answer that question by different explanations.Hunter saw the protective agent of the gastric mucosa against autodigestion in the principle of "life"—i. e., that living tissue cannot be digested.Claude Bernard1 contradicted Hunter by experimental proof, inasmuch

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