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Article
March 1914

COMPARATIVE STUDY OF PHENOLSULPHONEPHTHALEIN ELIMINATION AND THE INCOAGULABLE NITROGEN OF THE BLOOD IN CARDIORENAL DISEASES

Author Affiliations

ANN ARBOR, MICH.

From the Department of Internal Medicine, University of Michigan.

Arch Intern Med (Chic). 1914;XIII(3):485-496. doi:10.1001/archinte.1914.00070090138009
Abstract

INTRODUCTION  Since its introduction by Rowntree and Geraghty,1 the phenolsulphonephthalein test has to a great extent superseded all other tests of this class as an index of renal efficiency. The excretory ability of the kidney is measured by injecting a definite foreign substance and noting the amount eliminated within a definite time. Since Provost and Dumas2 found large quantities of urea in the blood of nephrectomized dogs, and since Babington working with Bright3 noted the large amount of urea in the blood of a nephritic, however, attention has been directed to the incoagulable nitrogen of the blood with the idea that its determination would indicate the permeability of the kidney to normal or abnormal nitrogenous metabolic products.A large number of observers4 have studied the urea of the blood and have noted a decided increase in patients with uremia, eclampsia, acute mercury poisoning and

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