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Article
May 1914

A METHOD DEVELOPED FOR OBTAINING A STANDARD WASSERMAN ANTIGEN

Arch Intern Med (Chic). 1914;XIII(5):790-793. doi:10.1001/archinte.1914.00070110119006
Abstract

This method has been developed in the Pathological Department of Bellevue Hospital during the past six months as a result of a study on the routine Wassermann reactions of five thousand patients. These patients have stayed in the hospital three days or longer ; otherwise there has been no choice of subjects.

For a long time it has been felt that the only variable reagent in the Wassermann reaction has been the antigen. Antigens have been made up from the alcoholic extracts of human syphilitic livers, human hearts and ox-hearts. The values of these various antigens have differed TABLE 1.—Readings with the Same

In Tables 1 and 2, 0 = complete hemolysis, 1 = marked hemolysis, 2 = slight hemolysis Twenty-three other cases were 0. All these cases were specific as to history or lesion. Forty other serums were negative.

considerably in each batch made up. This is apparently due to variations in

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