Such authorities as Senator,1 Osler,2 Bradford,3 Herrick4 and Forschheimer5 agree that in the treatment of acute nephritis a cautious trial with the use of diuretics may be made with safety, but that such drugs should not be given persistently unless a distinct effect is produced, since large doses or the continued effect of small doses may lead to scanty excretion of urine with retention of urinary products. The experimental evidence for this contention is slight.
Of the diuretics in clinical use, purin derivatives are given most extensively. The exact mechanism by which they produce diuresis is not altogether certain. Munk6 and Schwartz,7 from perfusion experiments on the isolated dog's kidney injected with caffein and allied drugs, found a marked diuresis without any evidence of increased flow of blood through the kidney, and concluded that these substances had a specific effect on renal
FITZ R. STUDY XXI: THE IMMEDIATE EFFECT OF REPEATED DOSES OF THEOBROMIN SODIUM SALICYLATE AND THEOCIN ON RENAL FUNCTION IN ACUTE EXPERIMENTAL NEPHRITIS. Arch Intern Med (Chic). 1914;XIII(6):945-956. doi:10.1001/archinte.1914.00070120107009