By the term "aplastic anemia" is understood a type of anemia differing in many respects from ordinary types of primary or secondary anemia but marked especially by retrogressive changes in the bonemarrow which result in a change of the normal red marrow to a fatty marrow. The term was first used by Ehrlich1 in 1888, in connection with an anemia of this type following severe uterine hemorrhage.
Isolated examples of aplastic anemia have since been reported and in 1908 Cabot2 collected reports of 24 authentic cases and discarded 11 other cases as incomplete or indefinite. In 1911 Hirschfeld3 in a discussion of the pathogenesis of the malady, gives briefly the essential features of 44 cases, of which 3 had been rejected and 12 accepted by Cabot. In the literature of the subject I have found 3 other cases, reported respectively by Crummer,4 by Stitt,
MUSSER JH. STUDY OF A CASE OF APLASTIC ANEMIA. Arch Intern Med (Chic). 1914;XIV(2):275-288. doi:10.1001/archinte.1914.00070140132006