The investigations of the Thompson-McFadden Pellagra Commission have been directed especially toward the study of the etiological factors in pellagra. We conceive this problem to include not only a study of the nature of the disease, the recognition and identification of the essential infecting or intoxicating agent, or the recognition of the dietary elements, the deficiency of which may give rise to pellagra, but also necessarily a study of the disease in its endemic centers, a study of the people who live there, their habits of life, their environment and occupations and their food, and, especially, a careful scrutiny of those respects in which the non-pellagrins of such a population differ from the pellagrins living in the same regions.
During the course of this work we have undertaken to record every known case of pellagra existing within a limited geographical district
SILER JF, GARRISON PE, MacNEAL WJ. INTRODUCTION TO THE SECOND PROGRESS REPORT OF THE THOMPSON-McFADDEN PELLAGRA COMMISSION. Arch Intern Med (Chic). 1914;XIV(3):289-292. doi:10.1001/archinte.1914.00070150002001