The general campaign against tuberculosis, and particularly the influence of tuberculosis sanatoriums, has kindled an eager interest in the early diagnosis of pulmonary tuberculosis. Treatment, to be availing, must be begun before the presence of moist râles in the lungs and tubercle bacilli in the sputum proclaims the destruction of tissue. The various biological tests, hypersensitiveness, complement fixation, agglutination, etc., that have lent such valuable aid in the diagnosis of other infectious diseases have failed in tuberculosis, because in tuberculosis, contrary to the conditions in other infections, infection and disease are not synonymous terms. Therefore, effort has been directed toward refining fundamental diagnostic methods. The symptomatology of tuberculous disease has been more thoroughly analyzed and many valuable symptomatic relations have been established. It is only exceptionally, however, that a diagnosis can be made from the symptoms alone, since similar symptoms and symptom-groups occur in many other conditions.
HAMMAN L, BAETJER FH. PULMONARY PHYSICAL SIGNS AND ROENTGEN-RAY FINDINGS IN HEALTHY ADULTS. Arch Intern Med (Chic). 1914;XIV(5):757-768. doi:10.1001/archinte.1914.00070170150010