Any procedure which will enable the clinician to determine the functional condition of an organ is most desirable. From the investigations of Wohlgemuth,1 Whnhausen2 and Noguchi3 on the quantitative estimation of diastatic activity in the blood, urine and feces, it seemed as though a method had been found which would show changes in the functional state of the pancreas. The results reported by these authors were obtained, not only in experimental pancreatic lesions in animals, but in pancreatic disease in man. Their work led to the present study.
The method employed to estimate diastatic activity was one devised by Wohlgemuth.4 The principle of the method is the conversion of starch into erythrodextrin, as determined by the iodin reaction. Wohlgemuth's modification of his method has been used in our investigation because of the short time in which it can be performed.Varying amounts
McCLURE CW, PRATT JH. A STUDY OF THE DIASTATIC ACTIVITY OF URINE AND FECES WITH SPECIAL REFERENCE TO DISEASES OF THE PANCREAS. Arch Intern Med (Chic). 1917;XIX(4):568-592. doi:10.1001/archinte.1917.00080230071008