Scope of the problem and general considerations.
Character of the cases and their general treatment.
Technic employed ; interpretation of results.
Dosage of optochin :
Oral administration entirely. The various methods of dosage used ; comparison. Relationship between body weight of patient and appearance of bactericidal action in the serum.
Combined intramuscular and oral administration.
Absorption and elimination.
Influence on the clinical course of the disease :
Occurrence of "spreads."
Duration of the disease.
The valuable studies of Morgenroth and his co-workers1 on the chemotherapy of the quinin alkaloids have shown that ethylhydrocuprein (optochin) has a specific bactericidal effect on the pneumococcus in vitro, and that this compound exerts a protective and curative action in animals experimentally infected with virulent strains of that micro-organism. The specific germicidal action of ethylhydrocuprein on the pneumococcus
MOORE HF, CHESNEY AM. A STUDY OF ETHYLHYDROCUPREIN (OPTOCHIN) IN THE TREATMENT OF ACUTE LOBAR PNEUMONIA. Arch Intern Med (Chic). 1917;XIX(4):611-682. doi:10.1001/archinte.1917.00080230114010