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Article
April 1917

A STUDY OF ETHYLHYDROCUPREIN (OPTOCHIN) IN THE TREATMENT OF ACUTE LOBAR PNEUMONIA

Author Affiliations

NEW YORK

From the Hospital of The Rockefeller Institute for Medical Research, New York.

Arch Intern Med (Chic). 1917;XIX(4):611-682. doi:10.1001/archinte.1917.00080230114010
Abstract
  • Historical.

  • Scope of the problem and general considerations.

  • Character of the cases and their general treatment.

  • Technic employed ; interpretation of results.

  • Dosage of optochin :

  • Oral administration entirely. The various methods of dosage used ; comparison. Relationship between body weight of patient and appearance of bactericidal action in the serum.

  • Combined intramuscular and oral administration.

  • Absorption and elimination.

  • Fastness.

  • Toxic effects.

  • Influence on the clinical course of the disease :

  1. Occurrence of "spreads."

  2. Pneumococcal septicemia.

  3. Duration of the disease.

  4. Mortality rate.

  • Discussion.

  • Conclusions.

HISTORICAL  The valuable studies of Morgenroth and his co-workers1 on the chemotherapy of the quinin alkaloids have shown that ethylhydrocuprein (optochin) has a specific bactericidal effect on the pneumococcus in vitro, and that this compound exerts a protective and curative action in animals experimentally infected with virulent strains of that micro-organism. The specific germicidal action of ethylhydrocuprein on the pneumococcus

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