The question of the effect of anesthetics on the kidney has long been one of interest, and it seemed to us that an investigation of this by means of the phenolsulphonephthalein test of Rowntree and Geraghty would be of considerable interest. No extensive investigation of the subject in this manner has come to our attention, though a brief report is given by Sanford1 who did the test in a series of cases of ether and gas-oxygen anesthesia, doing it first twenty-four hours before operation and again within a few hours afterward. He says :
The cases of gas anesthesia gave almost the same output of phthalein after anesthesia as before, showing apparently no effect on the kidney from the anesthetic. The ether cases have been rather contradictory. In short anesthetics the output of the drug was almost doubled after ether, and in long operations it was generally diminished.
MILLER RH, CABOT H. THE EFFECT OF ANESTHESIA AND OPERATION ON THE KIDNEY FUNCTION, AS SHOWN BY THE PHENOLSULPHONEPHTHALEIN TEST. Arch Intern Med (Chic). 1915;XV(3):369–391. doi:10.1001/archinte.1915.00070210030003