Metastatic calcification would seem to be a rare condition, if estimated by the number of cases reported in the literature, but it is undoubtedly often overlooked, and many cases that are recognized are probably not recorded. In 1911 I was able to collect from the literature but twenty-nine cases,1 and since that time there have been but two more cases recorded (those of M. B. Schmidt2 and Schober3) so far as I can find. The small number of cases published, and especially the important bearing this condition of metastatic calcification has on the general problems of calcium metabolism, ossification and pathological calcification, makes each additional case worthy of study and report.
By metastatic calcification is implied that the wide-spread deposition of calcium salts is a result of their excessive absorption from the normal depots, and excludes instances in which wide-spread tissue injury is the primary
WELLS HG. METASTATIC CALCIFICATION. Arch Intern Med (Chic). 1915;XV(4):574-580. doi:10.1001/archinte.1915.00070220076008