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A comparison of the second edition of Dr. Wells' chemical pathology with the first edition, published seven years before, gives interesting evidence of the lines along which the chemical study of disease has progressed and an equally striking demonstration of the scantiness of our knowledge of the exact chemical nature of the complex substances concerned in the production of disease and in the organism's defense against it. Dr. Wells does not confine himself to a statement of actual chemical knowledge of pathological lesions and processes in the strict sense, but gives a short survey of the chemistry and physics of the cell, of the nature and action of enzymes and anti-enzymes, and of bacteria and animal parasites and the poisons produced by them, as well as the poisons manufactured by the higher animal organisms.
In these earlier chapters one notes as new especially the discussion of the doubly refractive
Chemical Pathology.. Arch Intern Med (Chic). 1915;XV(4):643-644. doi:10.1001/archinte.1915.00070220145012