The digestion of nuclear material and the production of purin bases therefrom has been discussed from three points of view: (1) the morphological destruction of the nucleus; (2) the digestion of the so-called nucleoproteids and nucleins ; and (3) the splitting of nucleic acid. The localization of the third stage, namely, nucleic acid digestion, has been unquestionably settled by the demonstration of a nuclease in the erepsin of a dog (Nakayama,1 1904) and of its absence from the gastric and pancreatic juices (Levene and Medigreceanu,2 1911). Confirmatory evidence is afforded by the work of London and Schittenhelm3 (1910) who found no difference in the nucleic acid metabolism of a normal dog as compared with animals in which the stomach or the pancreas had been removed, or those with a ligated pancreatic duct.
The morphological destruction of the nucleus has been the subject of much controversy since the
ATCHLEY DW. NUCLEAR DIGESTION AND URIC ACID EXCRETION IN A CASE OF TOTAL OCCLUSION OF THE PANCREATIC DUCT. Arch Intern Med (Chic). 1915;XV(5_1):654-658. doi:10.1001/archinte.1915.00070230011002