Ever since the description by Garrod in 1860 of his so-called thread test for uric acid in gouty blood, the finding of an excess of uric acid in the blood of patients suffering from joint diseases has been considered to point toward a diagnosis of gout. Within recent years Brugsch and Schittenhelm1 have stated that in normal human blood uric acid is absent. Its presence they consider as pointing to the existence of gout. This view has also been accepted by Gudzent2 who recommends his dialysis method for the detection of uric acid in blood as being of aid in the differential diagnosis of joint conditions.
That Brugsch still believes in the diagnostic value of uric acid tests is shown by the recent appearance of a paper from his laboratory3 describing a clinical method for the determination of this substance in blood. According to this procedure
FOLIN O, DENIS W. THE DIAGNOSTIC VALUE OF URIC ACID DETERMINATIONS IN BLOOD. Arch Intern Med (Chic). 1915;XVI(1):33-37. doi:10.1001/archinte.1915.00080010038002