July 1915


Author Affiliations


From the laboratory of chemistry of the University of Washington and the laboratory of physiology of the Harvard Medical School.

Arch Intern Med (Chic). 1915;XVI(1):98-108. doi:10.1001/archinte.1915.00080010103008

I. INTRODUCTION  The study of the toxic nature of urine has interested investigators for many years. The continued attraction which this subject affords is no doubt due to the part which urinary retention plays in the vital economy. When it occurs it may produce only headache and a general malaise, yet it cuts down the efficiency to a marked degree. In severer cases it may lead to grave symptoms and even death.In attempting to account for this poisoning investigators have more often attributed it to a single urinary constituent. But a few have concluded that it was due to a number of substances.In the study of a new substance1 which is found in all urines, it was noticed that this substance, called urinod, produced headache and malaise. This led to a more careful investigation of its toxic nature. From experiments conducted thus far, urinod seems to be

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