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September 1915

METABOLISM STUDIES BEFORE AND AFTER SPLENECTOMY IN CONGENITAL HEMOLYTIC ICTERUS

Author Affiliations

From the John Herr Musser Department of Research Medicine, University of Pennsylvania.

Arch Intern Med (Chic). 1915;XVI(3):437-455. doi:10.1001/archinte.1915.00080030098008
Abstract

In this communication we present the results of a study of the metabolism, before and after splenectomy, in a child 5 years of age suffering from congenital hemolytic icterus with splenomegaly. As Dr. S. McC. Hamill, to whom we are indebted for the opportunity of making these studies, will, in a later communication, offer a consideration of the clinical and therapeutic problems involved, we will, aside from the metabolic studies, present only a brief abstract of the clinical history, a note on the pathology of the removed spleen and a table (Table 1) of the blood examinations before and after operation.

ABSTRACT OF CLINICAL HISTORY  At birth, at term, the child weighed 7 pounds and is described as lacking the characteristic red color of the newly born. About twenty-four hours after birth the "alabaster whiteness" of the skin, which the mother describes, changed to a mahogany brown which

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