Children frequently exhibit meningeal symptoms as a manifestation of diseases other than meningitis. The frequency of such symptoms seems to vary in inverse proportion to the age of the child. Thus, infants may show meningeal symptoms in association with almost any disease, while in older children, these symptoms are usually seen only in diseases involving the brain or meninges. Notwithstanding the value of a bacteriological examination, cell count and globulin estimation on spinal fluid, clear fluids are quite frequently obtained on which these examinations throw no light. The great variability in the cytology of the cerebrospinal fluid under the same conditions and the difficulty often encountered in demonstrating the presence of micro-organisms in a clear fluid, make every new aid to diagnosis welcome.
It is particularly in the cases with clear fluids that the permanganate reduction test of Mayerhofer is often of great assistance in
HOFFMAN WO, SCHWARTZ AB. THE PERMANGANATE REDUCTION INDEX OF CEREBROSPINAL FLUID. Arch Intern Med (Chic). 1916;XVII(2):293-302. doi:10.1001/archinte.1916.00080080115008