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April 1916

A STUDY OF THE BLOOD IN HEMOPHILIA

Author Affiliations

SAN FRANCISCO

From the George Williams Hooper Foundation for Medical Research and the pediatric Clinic, The University of California Medical School.

Arch Intern Med (Chic). 1916;XVII(4):543-569. doi:10.1001/archinte.1916.00080100087009
Abstract

INTRODUCTION  During the past few years the etiology of the hemorrhagic diseases has been the subject of considerable study. The progress made in this direction has been due largely to an increase in our knowledge of the physiology of blood coagulation and to the development of new methods of study. The literature of this period, indeed, has even given promise of an etiologic classification of hemorrhagic disease, but to the present time this goal has only been partly attained.It has been possible, for instance, to demonstrate that certain of the hemorrhagic conditions are associated with a deficiency in one or another factor of coagulation : there are on record instances of hemorrhagic disease associated with abnormalities in the prothrombin and antithrombin content of the blood.1 There is also experimental evidence of the existence of certain types of hepatic disease with some tendency to abnormal bleeding due to

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