[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 50.16.52.237. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
May 1916

OBSERVATIONS ON THE TYPHOIDIN REACTION

Author Affiliations

BALTIMORE

From the Medical Clinic of the Johns Hopkins Hospital.

Arch Intern Med (Chic). 1916;XVII(5):663-669. doi:10.1001/archinte.1916.00080110076006
Abstract

In every community in which typhoid fever is endemic, the desire exists for a method of determining the presence or absence of immunity to the disease.

A test that could be relied on to furnish an index of resistance to invasion by the typhoid bacillus, would determine the need of prophylactic vaccination or revaccination, and in certain less common instances, perhaps afford the means of identifying a previous obscure infection as typhoid fever. The shortcomings of the ordinary immunological procedures for this purpose, long recognized, were emphasized anew by Gay and his co-workers, who devised the typhoidin reaction to supplement them.

Gay and Force1 prepared an extract of the typhoid bacillus according to the technic employed by Koch in the preparation of "Original Tuberculin ;" 250 c.c. of 5 per cent. glycerin broth were inoculated with a strain of Bacillus typhosus (Dorset Army Strain No. 5), and

First Page Preview View Large
First page PDF preview
First page PDF preview
×