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Article
July 1916

THE HEREDITARY FACTOR IN PELLAGRA

Author Affiliations

COLD SPRING HARBOR, LONG ISLAND, N. Y.

From the Eugenic Record Office, at Cold Spring Harbor, Long Island, N. Y. This paper forms a part of the third report of the Robert M. Thompson Pellagra Commission of the New York Post-Graduate Medical School and Hospital.

Arch Intern Med (Chic). 1916;XVIII(1):4-31. doi:10.1001/archinte.1916.00080140009002
Abstract

I. Statement of the Problem  In certain parts of our country, and above all in our southern states, there are occasionally seen persons whose hands, feet and even other parts of the body show chronic, symmetrically placed,1 eczema-like rough patches or a formation of bullae and desquamation over larger or smaller areas. A condition of dermatitis may be due to a number of causes; to tuberculosis, to a filamentous fungus, to poisoning from without or within. Particularly the poison that can be expressed from certain mucors will, when injected into the veins of a rabbit, cause extensive desquamation of a similar sort. But in certain of these persons there is, in addition to the chronic desquamation, a persistent diarrhea or dysentery.2 In consequence of a disturbing factor, probably a tissue poison, of whose presence these are merely indications, the affected person is liable to die ; or

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