Hemophilia on account of its striking nature was early recognized as a clinical entity, and has been the subject of many observations. Many theories as to its causation have been advanced. With the development of methods for the study of the blood it has been possible to discard most of the theories concerning this interesting disease.
It has been conclusively shown that in typical cases the numerical counts of the formed elements of the blood, the erythrocytes and the leukocytes are within normal limits. The blood platelets may be somewhat increased. It has also been shown in typical cases that certain active principles of the blood that participate in clotting occur in normal amounts. The hemophilic blood serum1 contains the normal amount of thrombin, the active coagulating principle, and this thrombin behaves in an entirely normal fashion. It has further been shown that the hemophilic blood clot,
MINOT GR, LEE RI. THE BLOOD PLATELETS IN HEMOPHILIA. Arch Intern Med (Chic). 1916;XVIII(4):474-495. doi:10.1001/archinte.1916.00080170047004