October 1916


Author Affiliations


From the John Herr Musser Department of Research Medicine of the University of Pennsylvania, Philadelphia.

Arch Intern Med (Chic). 1916;XVIII(4):551-556. doi:10.1001/archinte.1916.00080170124010

INTRODUCTION  The subject of this investigation is a woman suffering at irregular intervals from attacks of transient edema, sometimes with convulsions, and with a persistent but variable eosinophilia. She has been under observation, more or less constantly, in the wards of the university hospital for a period of eight years and has been during that time the subject of many detailed studies, planned with the object of throwing some light on the etiology or exact nature of her condition. These, however, have yielded no specific information and the condition remains diagnosed only as an obscure type of angioneurotic edema. The present studies are an attempt to demonstrate any changes which may have occurred concomitantly with the attacks of edema, and include a determination of nitrogen utilization; an estimation of the acid-base relations of the body fluids ; a study of the chlorid excretion ; and uncompleted desultory studies of calcium and fat

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