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Article
July 1917

STUDY OF A CASE OF DIABETES INSIPIDUS WITH SPECIAL REFERENCE TO THE MECHANISM OF THE DIURESIS AND OF THE ACTION OF PITUITARY EXTRACT ON IT

Author Affiliations

CLEVELAND

From the Department of Medicine of Lakeside Hospital and the H. K. Cushing Laboratory of Experimental Medicine, Western Reserve University.

Arch Intern Med (Chic). 1917;XX(1):10-23. doi:10.1001/archinte.1917.00090010017002
Abstract

The case of diabetes insipidus reported in this paper presented, on account of the high degree of the diuresis, an unusually good opportunity for the study of certain points in connection with the mechanism of the diuresis and the influence on it of extracts of the posterior lobe of the pituitary body. Although it was not possible to induce the patient to remain long enough in the hospital to enable us to complete our program, the results obtained seem worthy of being recorded.

The manner in which the excretion of water by the kidney is regulated has formed the subject of recent papers by Priestley1 and by Haldane and Priestley.2 They find, as T. M. Wilson,3 working under the direction of one of us, previously showed, that the drinking of water is followed by a small diminution of the specific conductivity of the blood serum. According to Wilson, the meaning

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