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October 1917


Author Affiliations


From the Medical Clinic of the Peter Bent Brigham Hospital.

Arch Intern Med (Chic). 1917;XX(4):481-514. doi:10.1001/archinte.1917.00090040003001

"Without uric acid, no gout," has been for many years a generally accepted dictum. And yet in spite of many investigations the relation of uric acid to gout has not been clearly established. In the diagnosis of gout by chemical means the same uncertainty exists. The uric acid may be increased in the blood and diminished in the urine, but the diagnostic value of these findings is doubtful. The development of new methods in biochemistry within the past few years permits a more thorough study of the factors governing the excretion of uric acid, and for this reason we have reinvestigated this subject.

Our studies on gout have been along the following four lines:

  1. A comparison of the uric acid content of the blood in the gouty and in the nongouty.

  2. The results obtained by the intravenous injections of uric acid in the gouty and in the nongouty.

    A comparison of

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