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Article
February 1918

THE NATURE OF THE PATHOLOGIC PROCESS IN PROGRESSIVE MUSCULAR DYSTROPHY

Arch Intern Med (Chic). 1918;XXI(2):256-262. doi:10.1001/archinte.1918.00090080083007
Abstract

In progressive muscular dystrophy we find: (a) low blood sugar, and, following suitable treatment, a rise in blood sugar accompanied by an increase in strength; (b) creatinuria; (c) low cholesterin content of the blood — three independent testimonies of disturbed carbohydrate metabolism.1

The condition of low blood sugar and parallelism between muscular strength and blood sugar speaks for itself.

Creatin is not known to occur in the urine of men except as an accompaniment of some disturbance of carbohydrate metabolism. It accompanies diabetes and starvation. In dogs it accompanies hydrazin poisoning,2 and phlorizin poisoning,3 conditions resulting in hypoglycemia.4 In the rabbit, an animal in which hypoglycemia does not always follow hydrazin poisoning, creatinuria occurs only in those cases in which hypoglycemia does follow.5

A low cholesterin content of the blood accompanies hypoglycemia;1 a high cholesterin content is associated with hyperglycemia.6

The glucose of the blood is the source of energy

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