July 1918


Author Affiliations

From the Laboratories of Physiology, Pharmacology and Physiological Chemistry, University of Pittsburgh School of Medicine.

Arch Intern Med (Chic). 1918;XXII(1):1-7. doi:10.1001/archinte.1918.00090120006001

INTRODUCTION  It has been stated that in shock liquid passes from the blood to the tissues,1 resulting in alterations of physical condition, as increased specific gravity, red cell count, viscosity, and decrease in total blood volume.In an investigation of experimental shock in dogs,2 the blood was studied to determine if such alterations occurred in the type of shock induced, and if there was a causal relation between blood change and shock.

METHODS AND RESULTS  Dogs under ether anesthesia were reduced to a state of shock, essentially by nerve stimulation.3 Some blood was lost by operative procedures and by taking samples for analyses, but in no case was such loss in itself of sufficient magnitude to induce shock. In typical cases the blood pressure was greatly lowered, the cardiac output was decreased—as indicated by diminished pulse pressure and volume—respiration was irregular, eye reflexes were present and slight if any tendency

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