July 1918


Arch Intern Med (Chic). 1918;XXII(1):82-85. doi:10.1001/archinte.1918.00090120087008

The occurrence of alkaptonuria is sufficiently rare to justify the publication of the following case. Only nine of the seventy or so recorded cases of alkaptonuria have been reported occurring in the states.

As the exact cause of this condition is still unknown and as relatively few cases have been reported, it seemed well to add this record to those which have been published, with the findings and result of treatment. Fromherz has recently expressed the opinion that many alkaptonurics remained unnoticed, and he calls attention to the fact that forty-five of the seventy cases have been reported within the last fifteen years.

The term alkaptone (from alkali and káπTELV, "to absorb greedily") was first ascribed by Bödeker in 1857 to a substance found in the urine of a patient, which possessed two chief characteristics: first, the power to reduce alkaline copper solutions, and secondly, the property of absorbing oxygen

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