July 1918


Author Affiliations


From the Hospital of the Rockefeller Institute for Medical Research.

Arch Intern Med (Chic). 1918;XXII(1):96-113. doi:10.1001/archinte.1918.00090120101010

INTRODUCTION  The glucose content of normal human urine is under 0.1 per cent., usually merely a trace. The kidneys normally excrete urine containing a lower concentration of glucose than is found in the blood. When the kidneys show a higher permeability for glucose, sugar should appear in the urine while the tissues still retain the normal power of utilizing dextrose. So-called "renal glycosuria" occurs on account of an abnormal permeability of the kidneys, without any disturbance of intermediary carbohydrate metabolism. In such a condition there are no diabetic symptoms and the blood sugar is normal.The existence of this condition was first declared by Klemperer1 at the Congress of Internal Medicine, in Berlin, 1896, and the conditions for its diagnosis were given as follows:

  1. The glycosuria has almost no relation to the quantity of carbohydrate in the diet.

  2. Not only is there no hyperglycemia, but sometimes even hypoglycemia.

  3. When nephritis occurs

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