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August 1918


Author Affiliations


From the Laboratory of Internal Medicine, The Henry Phipps Psychiatric Clinic, Johns Hopkins Hospital.

Arch Intern Med (Chic). 1918;XXII(2):245-268. doi:10.1001/archinte.1918.00090130121009

The first question to be decided in describing the treatment of general paresis is that of the diagnosis. In this clinic we subdivide neurosyphilis into two main types, the mesoblastic and the parenchymatous; thus making the anatomic lesion coincide more or less with the clinical picture.

The mesoblastic type of neurosyphilis is again subdivided into the endarteritic, the meningitic, and the gummatous forms. Since it is not our intention to describe the treatment of these particular forms, we content ourselves with merely mentioning them.

Parenchymatous syphilis of the central nervous system is differentiated, first, according to the location of the lesion, and secondly, according to the clinical picture. Thus, we distinguish between tabes and general paresis, and can further speak of a diffuse cerebral, a focal cerebral, a cerebellar and a tabetic type of the latter disease. We can also speak of a simple dementing type, an expansive type, a

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