Our review of the literature (MEDLINE searched 1966-March 2001) established that amelanotic melanoma represents 1.8% to 8.1% of cutaneous malignant melanoma.1 Amelanotic melanoma often goes clinically undiagnosed because of its wide range of clinical appearances and lack of pigmentation. Little is known about the role of mechanical trauma in the pathogenesis of melanoma. We have been unable to find references in the literature concerning the occurrence of amelanotic melanoma in connection with scars but report 2 clinical cases of amelanotic melanoma that had developed on a posttraumatic scar.
Redondo P, Solano T, Bauza A, Lloret P. Amelanotic Melanoma Presenting as a Scar. Arch Intern Med. 2001;161(15):1912-1913. doi: