Comments, Opinions, and Brief Case Reports
August 12/26, 2002

Association Between Folic Acid Food Fortification and Hypertension or Preeclampsia in Pregnancy

Author Affiliations

Copyright 2002 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2002

Arch Intern Med. 2002;162(15):1776-1777. doi:

From April 1990 to March 2000, the overall rate of preeclampsia did not significantly change before (3.8%) and after (3.7%) the introduction of a mandatory Canadian folic acid food fortification program in January 1998.

Both folate deficiency and elevated plasma homocysteine are associated with an increased risk of the placenta-mediated diseases of pregnancy, including preeclampsia-eclampsia (PET).1 By January 1998, flour producers were fortifying all Canadian flour in compliance with a mandatory national program, providing an additional daily average of 0.1 mg of folic acid (G. Carson, Robin Hood Multifoods Inc, Markham, Ontario, written communication, August 2000). We conducted a retrospective population-based longitudinal study to assess whether the introduction of this folic acid fortification program was associated with a decline in the rate of PET and all hypertensive disorders of pregnancy.

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