August 11/25, 2003

Aortic StenosisA New Face for an Old Disease

Author Affiliations

Copyright 2003 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2003

Arch Intern Med. 2003;163(15):1769-1770. doi:10.1001/archinte.163.15.1769

WHEN I WAS a second-year medical student in the 1960s, one of the first patients I was shown was a man with severe aortic stenosis secondary to rheumatic heart disease. I still remember this patient's face and the distinctive, rough, systolic ejection murmur that filled systole, obliterating the second heart sound. Since then, rheumatic cases of aortic stenosis have become rare, but severe aortic stenosis is still one of the commonest causes of valvular heart disease seen in hospitalized patients. In the more than 30 years since I saw my first patient with aortic stenosis, much has been learned concerning the pathophysiology of this condition. Indeed, there are studies currently under way seeking to alter the pathological sequence in this disease that eventually leads to aortic valve replacement.

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