In their letter, Giannini and Testa describe the discordance between health risks across race groups and components of the metabolic syndrome as defined by the Adult Treatment Panel (ATP) III criteria.1 Each of the 5 potential components that make up the ATP III definition of metabolic syndrome are equally weighted, and the diagnosis is established when a patient has any 3 or more of the empirically defined risk factors. These collective risk factors are aimed at identifying subjects with the insulin resistance phenotype who are at increased risk of developing cardiovascular disease and adult-onset diabetes mellitus.
Park Y, Zhu S, Heymsfield SB, Heshka S. The Metabolic Syndrome: All Criteria Are Equal, but Some Criteria Are More Equal Than Others—Reply. Arch Intern Med. 2003;163(22):2788. doi:10.1001/archinte.163.22.2787