We read with great interest the recent article by Margolis et al.1 Clearly, this study highlights the importance of further investigating one of the cornerstones of the inflammatory response as it pertains to the pathogenesis of CHD. As Cushman2 points out in her accompanying editorial, one wonders to what extent the neutrophils are responsible for this predictive effect of the WBC count.
Kowolik MJ, Dowsett SA. Leukocyte Response to Dental Plaque Accumulation: A Risk Factor for Heart Disease?. Arch Intern Med. 2005;165(15):1795–1796. doi:10.1001/archinte.165.15.1795-c