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Figure 1. Risk periods for the self-controlled case series study. AP indicates antipsychotic agent; RAMQ, Régie de l’Assurance Maladie du Québec.

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Figure 2. One-year myocardial infarction–free survival and incidence of myocardial infarction among community-dwelling older patients with treated dementia in the exposed subcohort (incident users of antipsychotic agents) vs the unexposed subcohort (nonusers).

Table 1. Characteristics of Community-Dwelling Older Patients With Treated Dementia in the Exposed Subcohort (Incident Users of Antipsychotic Agents) vs the Unexposed Subcohort (Nonusers)
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Table 2. Retrospective Cohort Study of the Association Between Antipsychotic Use and Myocardial Infarction (MI)
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Table 3. Self-controlled Case Series Study of 804 Incident Cases of Myocardial Infarction (MI) Among New Users of Antipsychotic Agents
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Original Investigation
Apr 23, 2012

Antipsychotic Use and Myocardial Infarction in Older Patients With Treated Dementia

Author Affiliations

Author Affiliations: Faculty of Pharmacy, Université de Montreal (Drs Pariente and Moride and Mr Ducruet), and Pharmacoepidemiology Unit, Research Center, University of Montréal Hospital Center (Dr Moride, Mr Ducruet, and Ms Béland), Montreal, Quebec, Canada; Unité 657 (Drs Pariente, Moride, Moore, and Fourrier-Réglat) and Unité 897 (Dr Dartigues), Institut National de la Santé et de la Récherche Médicale, Université Bordeaux Ségalen, and Centre Hospitalier Universitaire de Bordeaux, Pharmacology (Drs Pariente, Moore, and Fourrier-Réglat) and Neurology (Dr Dartigues) Departments, Bordeaux, France; and Department of Mathematics and Statistics, The Open University, Milton Keynes, England (Dr Farrington).

Arch Intern Med. 2012;172(8):648-653. doi:10.1001/archinternmed.2012.28