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Figure.
PSA Testing Among PCPs and Urologists in Men Aged 50 to 74 Years Before and After the 2012 USPSTF Screening Recommendations
PSA Testing Among PCPs and Urologists in Men Aged 50 to 74 Years Before and After the 2012 USPSTF Screening Recommendations

Odds ratios (ORs) demonstrate the association between year and odds of undergoing prostate-specific antigen (PSA) testing within each physician group. The interaction term of physician specialty × survey year assessed the heterogeneity of PSA testing practices. Complex samples logistic regression models adjusted for race/ethnicity, rectal examination at time of PSA test, significant physician characteristics, and patient comorbidities. PCP indicates primary care physician. Light blue line represents urologists; dark blue line, PCPs. The dashes provide a visual cue of the change in screening frequency following the new recommendations.

1.
Penson  DF.  The pendulum of prostate cancer screening.  JAMA. 2015;314(19):2031-2033.PubMedArticle
2.
US Preventive Services Task Force.  Final recommendation statement: prostate cancer: screening, May 2012. http://www.uspreventiveservicestaskforce.org/Page/Document/RecommendationStatementFinal/prostate-cancer-screening. Accessed January 19, 2016.
3.
Sammon  JD, Abdollah  F, Choueiri  TK,  et al.  Prostate-specific antigen screening after 2012 US Preventive Services Task Force recommendations.  JAMA. 2015;314(19):2077-2079.PubMedArticle
4.
Jemal  A, Fedewa  SA, Ma  J,  et al.  Prostate cancer incidence and PSA testing patterns in relation to USPSTF screening recommendations.  JAMA. 2015;314(19):2054-2061.PubMedArticle
5.
Sammon  JD, Pucheril  D, Diaz  M,  et al.  Contemporary nationwide patterns of self-reported prostate-specific antigen screening.  JAMA Intern Med. 2014;174(11):1839-1841.PubMedArticle
6.
Carter  HB, Albertsen  PC, Barry  MJ,  et al.  Early detection of prostate cancer: AUA guideline.  J Urol. 2013;190(2):419-426.PubMedArticle
Research Letter
April 2016

Differences in Prostate-Specific Antigen Testing Among Urologists and Primary Care Physicians Following the 2012 USPSTF Recommendations

Author Affiliations
  • 1Center for Surgery and Public Health, Brigham and Women’s Hospital, Boston, Massachusetts
  • 2Division of Urological Surgery, Brigham and Women’s Hospital, Boston, Massachusetts
JAMA Intern Med. 2016;176(4):546-547. doi:10.1001/jamainternmed.2015.7901

The use of prostate-specific antigen (PSA) testing for early detection of prostate cancer remains controversial.1 In October 2011, the US Preventive Services Task Force (USPSTF) issued a recommendation against PSA screening for all men.2 This change was associated with a decline in rates of PSA testing among men aged 50 to 74 years and a decline in cases of incident prostate cancer.3,4 Given the evidence for heterogeneity in screening practices,5 we sought to compare the use of PSA testing among urologists vs primary care physicians (PCPs) before and after the latest USPSTF guidelines, hypothesizing that the adoption of these recommendations would vary according to physician specialty.

Methods

We used the National Ambulatory Medical Care Survey to examine the use of PSA testing in 2010 (conducted between December 28, 2009, and December 26, 2010) and 2012 (conducted between December 28, 2011, and December 26, 2012). The National Ambulatory Medical Care Survey is an annual, nationally representative survey of ambulatory care in the United States that collects information about outpatient physician visits, patient demographics, diagnoses, medications, and indications for consultation. Specialty of health care professionals was dichotomized as urologist and PCP (general and family practice and internal medicine). We examined the frequency of PSA testing according to specialty and year to evaluate the association between the 2012 USPSTF recommendations and changes in PSA testing among men aged 50 to 74 years. Heterogeneity in testing practices between physicians was modeled by assessing the interaction term of physician specialty × survey year within a logistic regression model estimating probability of PSA testing. Results were weighted to reflect the US population based on the complex survey design. A 2-tailed level of significance was set at P < .05. The Brigham and Women’s Hospital Institutional Review Board waived approval for the study. Data analysis was conducted from July 21 to November 16, 2015.

Results

We included all visits for men aged 50 to 74 years (n = 1222) who presented to urologists (113 [9.2%]) or PCPs (1109 [90.8%]) for a preventive care visit. Men with a diagnosis of prostate cancer (n = 18), elevated PSA level (n = 1), benign prostatic hyperplasia (n = 31), prostatitis (n = 5), or other unspecified disorders of the prostate (n = 3) were excluded. This exclusion resulted in a weighted sample of 27 million eligible visits (unweighted n = 1164) in 2010 and 2012, of which 800 000 (unweighted n = 64) were provided by urologists and 26.2 million (unweighted n = 1100) by PCPs. The use of PSA testing decreased from 36.5% to 16.4% among PCP visits (adjusted odds ratio, 0.44; 95% CI, 0.24-0.80), whereas it decreased from 38.7% to 34.5% among urologist visits (adjusted odds ratio, 0.60; 95% CI, 0.19-1.84). The difference between physician-specific testing practices during the study years was not statistically significant (P = .63) (Figure).

Discussion

Despite the nonsignificance of the interaction analysis, likely the result of a small sample size, the contrasting temporal trends of PSA testing suggest a differential effect of the 2012 USPSTF recommendations on PSA testing among PCPs vs urologists. Our observations may reflect opposing perceptions among physicians on the benefit of PSA screening, conflicting guidelines (eg, the American Urological Association recommends joint decision making for men aged 55-69 years),6 and perhaps differences in patient demographics or expectations. Moving forward, this finding emphasizes the need to continue interdisciplinary dialogue to achieve a broader consensus on prostate cancer screening.

Certain limitations to our study must be considered. As our study relied on records of outpatient clinic visits, our findings may differ from those of other studies using self-reports of PSA testing. Second, we do not account for PSA testing outside of physician outpatient visits. Third, our findings reflect orders for PSA testing, which may differ from actual testing performed. Owing to the lack of numeric PSA values, we could not account for the definition of elevated PSA levels. Fourth, we are not able to account for PSA testing performed on a separate visit (including those by another type of physician). Finally, our findings are based on a sample of incident visits rather than a longitudinal follow-up over time.

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Article Information

Corresponding Author: Quoc-Dien Trinh, MD, Division of Urological Surgery, Brigham and Women’s Hospital, 45 Francis St, Boston, MA 02115 (qtrinh@bwh.harvard.edu).

Correction: This article was corrected on August 15, 2016, to fix an error in reported odds ratios.

Published Online: February 8, 2016. doi:10.1001/jamainternmed.2015.7901.

Author Contributions: Dr Trinh had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Drs Meyer and Zavaski contributed equally to the study.

Study concept and design: Zavaski, Meyer, Sammon, Hanske, Sun, Trinh.

Acquisition, analysis, or interpretation of data: Zavaski, Meyer, Sammon, Gupta, Trinh.

Drafting of the manuscript: Zavaski, Trinh.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Zavaski, Meyer, Hanske, Gupta.

Administrative, technical, or material support: Meyer.

Study supervision: Meyer, Sammon, Sun, Trinh.

Conflict of Interest Disclosures: None reported.

Funding/Support: This study was supported by an unrestricted educational grant from the Vattikuti Urology Institute and the Professor Walter Morris-Hale Distinguished Chair in Urologic Oncology at Brigham and Women’s Hospital (Dr Trinh).

Role of the Funder/Sponsor: The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

References
1.
Penson  DF.  The pendulum of prostate cancer screening.  JAMA. 2015;314(19):2031-2033.PubMedArticle
2.
US Preventive Services Task Force.  Final recommendation statement: prostate cancer: screening, May 2012. http://www.uspreventiveservicestaskforce.org/Page/Document/RecommendationStatementFinal/prostate-cancer-screening. Accessed January 19, 2016.
3.
Sammon  JD, Abdollah  F, Choueiri  TK,  et al.  Prostate-specific antigen screening after 2012 US Preventive Services Task Force recommendations.  JAMA. 2015;314(19):2077-2079.PubMedArticle
4.
Jemal  A, Fedewa  SA, Ma  J,  et al.  Prostate cancer incidence and PSA testing patterns in relation to USPSTF screening recommendations.  JAMA. 2015;314(19):2054-2061.PubMedArticle
5.
Sammon  JD, Pucheril  D, Diaz  M,  et al.  Contemporary nationwide patterns of self-reported prostate-specific antigen screening.  JAMA Intern Med. 2014;174(11):1839-1841.PubMedArticle
6.
Carter  HB, Albertsen  PC, Barry  MJ,  et al.  Early detection of prostate cancer: AUA guideline.  J Urol. 2013;190(2):419-426.PubMedArticle
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