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Article
June 1921

THE TOTAL NONPROTEIN NITROGEN CONSTITUENTS OF THE BLOOD IN ARTERIAL HYPERTENSION

Author Affiliations

CHICAGO

From the Pathological Laboratory, St. Luke's Hospital; aided by the Seymour Coman Fund.

Arch Intern Med (Chic). 1921;27(6):748-754. doi:10.1001/archinte.1921.00100120119008

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Abstract

Arterial hypertension is regarded frequently as a manifestation of chronic nephritis. In recent years, however, there is a growing belief that hypertension alone is not necessarily evidence of nephritis. Allbutt1 was among the first to recognize from clinical observations that hypertension may be present without nephritis; this condition he termed "hyperpiesis." Under the title "primary hypertensive cardiovascular disease," Janeway2 described the same disorder, while more recently Mosenthal3 and others have suggested the term "benign or essential hypertension." Krehl4 observed hypertension in a number of patients with other clinical symptoms not supporting the diagnosis of chronic nephritis. Gross and microscopic examination of the kidneys of one of these patients failed to reveal abnormal changes.

Until renal function was estimated by the phenolsulphonephthalein test and by the quantitative determination of the nonprotein nitrogen constituents of the blood, the evidence of the kidney disease obtained was chiefly anatomical or clinical. Mosenthal observed essential

References
1.
Allbutt, C.: Diseases of the Arteries, Including Angina Pectoris , London. Macmillan & Co. 1915
2.
 Arteriosclerosis and the Kidneys , Brit. M. J. 1:854, 922, 1911.
3.
Janeway, T. C.:  A Clinical Study of Hypertensive Cardiovascular Disease , Arch. Int. Med. 12:755 ( (Dec.) 1913.Article
4.
Mosenthal, H. O.:  Essential Hypertension , Med. Clin. N. America 1:101 ( (July) ) 1917.
5.
Krehl, L.: Deutsch. med. Wchnschr. 3:1872, 1905.Article
6.
Rappleye, W. C.:  The Kidney Function in 100 Cases of Hypertension , Boston M. & S. J. 179:441, 1918.
7.
Stengel, A.:  The Classification of Chronic Nephritis and the Relation of Infection to Kidney Disease , Med. Clin. N. America 1:217 ( (Sept.) ) 1917.
8.
Meara, F. S.:  Hyperpiesia of Clifford Allbutt , Med. Clin. N. America 2:1 ( (July) ) 1918.
9.
Folin, O., and Denis, W.:  The Diagnostic Value of Uric Acid Determination in the Blood , Arch. Int. Med. 16:33 ( (July) ) 1915.
10.
Myers, V. C.; Fine, M. S., and Lough, W. G.:  The Significance of Uric Acid, Urea and Creatinin of the Blood in Nephritis , Arch. Int. Med. 17:570 ( (April) ) 1916.
11.
Baumann, L.; Hansmann, G. H.; Davis, A. C., and Stevens, F. A.:  The Uric Acid of the Blood as Compared with the Renal Dietary Test , Arch. Int. Med. 24:70 ( (July) ) 1919.
12.
Allen, F. M.:  Arterial Hypertension , J. A. M. A. 74:652 ( (March 6) ) 1920.
13.
Hopkins, A. H.:  Climacteric Hypertension , Am. J. Med. Sc. 157:826, 1919.
14.
Van Slyke, D. D., and Cullen, G. E.: J. A. M. A. 62:1558 ( (May 16) ) 1914.
15.
Folin, O., and Wu, H.:  A System of Blood Analysis , J. Biol. Chem. 38:81, 1919.
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