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May 1961

Tularemia Vaccine StudyII. Respiratory Challenge

Author Affiliations


From the Department of Medicine, College of Medicine, Ohio State University, Columbus, Ohio. This study was supported under Contract with the U.S. Army CmlC, Fort Detrick, Frederick, Md.

Arch Intern Med. 1961;107(5):702-714. doi:10.1001/archinte.1961.03620050068007

Previous studies from these laboratories demonstrated that man can readily be infected by intracutaneous inoculation with approximately 10 Pasteurella tularensis organisms (SCHU S4 strain).1 Prior vaccination with killed Foshay vaccine did not prevent local lesions, but did reduce the incidence of systemic manifestations of infection. Review of accidental laboratory infection indicates that the respiratory route may serve as a portal of entry.2 Experimental respiratory infections can easily be induced in both vaccinated and nonvaccinated monkeys, and response to therapy is good.3 This present report describes the response to respiratory challenge with P. tularensis of nonvaccinated volunteers and of volunteers who received either killed vaccine or a viable attenuated vaccine.

Materials and Methods  Volunteers were inmates of the Ohio State Penitentiary, 21 to 35 years of age. Criteria for selection and conditions of volunteering have been described.1Vaccination with Foshay killed tularemia vaccine was conducted as previously

Saslaw, S.; Eigelsbach, H. T.; Wilson, H. E.; Prior, J. A., and Carhart, S.:  Studies with Tularemia Vaccines in Volunteers: I. Clinical Aspects Following Intracutaneous Challenge , Arch. Int. Med. , (this issue) , page 689.
Kadull, P. J.; Reames, H.; Coriell, L. L., and Foshay, L.:  Studies on Tularemia: V. Immunization of Man , J. Immunol. 65:425, 1950.
Eigelsbach, H. T.; Saslaw, S.; Fukui, G. M.; Wedum, A. G., and Albrink, W. S.: Tularemia Prophylaxis in the Monkey , to be published.
Eigelsbach, H. T.; Downs, C. M., and Herring, R. D.:  Comparative Immunogenicity of Live and Killed Tularemia Vaccines for the Mouse and Guinea Pig , Bacteriol. Proc. 1958:74, 1958.
Henderson, D. W.:  An Apparatus for the Study of Airborne Infection , J. Hyg. 50:53, 1952.Article
Saslaw, S., and Carhart, S.: To be published.