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Article
August 1963

Mechanism of Dehydration Following Alcohol Ingestion

Author Affiliations

SAN FRANCISCO

Associate Clinical Professor of Medicine, Stanford University School of Medicine, and Director of Research, Roberts Foundation and Clinic.

From the Department of Medicine and Clinical Physiology, St. Mary's Hospital.

Arch Intern Med. 1963;112(2):154-157. doi:10.1001/archinte.1963.03860020052002
Abstract

It is well established that the ingestion of alcohol is followed by a substantial diuresis.1 If sufficient alcohol is ingested, the diuresis occurs at the expense of all cellular components, and dehydration ensues. One explanation is that alcohol, or one of its metabolites, could be sufficiently small in size so as to be filtered at the renal glomerulus, and if renal tubular reabsorption were sluggish, it could be excreted in the urine and would cause an osmotic type of diuresis.

On the other hand, it has been postulated that alcohol inhibits the release of antidiuretic hormone "per se" and that the inhibition is sufficient to be the entire basis for diuresis. If this hypothesis is true, the osmotic concentration of the urine should decrease coincidentally to an increase in plasma osmotic pressure. In favor of this hypothesis is the finding that hypertonic saline given simultaneously prevents the diuretic effect of

References
1.
Shakespeare, W.: Macbeth, Act II, iii.
2.
Rubini, M. E.; Kleeman, C. R.; and Lamdin, E.:  The Effect of Ethyl Alcohol Ingestion on Water, Electrolytes and Acid-Base Metabolism , J Clin Invest 34:439, 1955.Article
3.
Kleeman, C. R.; Rubini, M. E.; Lamdin, E.; and Epstein, F. A.:  The Evaluation of Ethyl Alcohol as an Inhibitor of the Neurohypophysis , J Clin Invest 34:448, 1955.Article
4.
Strauss, M. B.; Rosenbaum, J. D.; and Nelson, W. P.:  An Effect of Alcohol on the Renal Excretion of Water and Electrolyte , J Clin Invest 29:1053, 1955.Article
5.
Nicholson, W., and Taylor, H. M.:  Effect of Alcohol on the Water and Electrolyte Balance in Man , J Clin Invest 17:279, 1938.Article
6.
Eggleton, M. G.:  The Diuretic Action of Alcohol in Man , J Physiol (London) 104:312, 1946.
7.
Verney, E. B.:  Absorption and Excretion of Water: The Anti-Diuretic Hormone , Lancet 2:739, 781, 1946.Article
8.
Roberts, K. E.: Clinical Physiology , San Francisco: Filmer Bros., 1961, vol 1.
9.
Gauer, O. H., et al:  The Effect of Negative Pressure Breathing on Urine Flow , J Clin Invest 33:287, 1954.Article
10.
Henry, J. P., et al:  Evidence of the Atrial Location of Receptors Influencing Urine Flow , Circulat Res 4:85, 1956.Article
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